麦当娜和圣徒与圣徒相处呈现出更加生动的画面，不仅是麦当娜对孩子的诞生感到高兴，而且还有其他几个人，包括寻求孩子的祝福的外行。意大利高级文艺复兴时期的艺术家拉斐尔（Raphael）曾画过着名的“麦当娜与圣徒儿童画”（The Madonna and the Child Enthroned with Saints）。 Damiani等人（363-371）认为，这幅画是这位艺术家在美国的唯一祭坛。这幅画也被称为科隆纳祭坛。这幅画从1504年至1505年完成，被认为是拉斐尔最后一笔落入私人手中的作品。大都会音频指南在线声称，这幅画是美术馆珍贵的藏品，被认为是当时的杰作。可以肯定的是，在绘画中使用许多人和在儿童身上略微举起的手可以被认为是孩子对周围人民的祝福。与Duccio的绘画相似，绘画的中心被麦当娜和孩子强调，但是从图2可以看出，不同的视角是显而易见的。可以认为，绘画具有与同一主题上的其他绘画一样的宗教倾向。
Madonna and Child Enthroned with Saints presents a more vivid picture wherein it is not just Madonna who is delighted by the birth of the child but also several others including the layman who seek blessings from the Child. The Italian High Renaissance artist Raphael had painted the famous painting The Madonna and the Child Enthroned with Saints. Damiani et al. (363-371) argues that this painting is the only altarpiece of this artist that is present in the United States. This painting is also known as the Colonna Altarpiece. This painting was completed from 1504 to 1505 and is considered as the last of the Raphael’s work that landed in private hands. Met Audio Guide Online claims that this painting is a prized possession for the Met museum and has been considered a masterpiece of its time. It can be verified that the use of a number of people in the painting and a slightly raised hand of the Child can be considered to as the blessings of the child to the peoples surrounding him. Similar to Duccio’s painting the centre of the painting is accentuated by Madonna and the Child, yet the different perspective is evident as can be observed from Image 2. It can be suggested that the painting has the religious inclination just like other paintings on the same subject.