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lun wen:治疗癌症药物的研究

lun wen:治疗癌症药物的研究

二甲双胍是一种治疗2型糖尿病的药物。该药物通过靶向AMP活化蛋白激酶(AMPK)起作用。这使得肌肉利用体内的葡萄糖。最近的研究表明,AMPK酶被用来调控蛋白激酶LKB1。这是一种肿瘤抑制剂。因此,本研究的目的是展示二甲双胍在降低糖尿病患者患癌症风险中的应用。以这一因素为背景,进行了研究,了解二甲双胍除了用于控制2型糖尿病的影响。

参与者:

使用Tayside数据库对一项试点病例对照研究进行了测试。该数据库名为糖尿病临床信息系统。对数据库中的糖尿病患者进行随机研究。所有的参与者都患有糖尿病,研究中的一些人患上了癌症,而其他人没有任何癌症的迹象。

lun wen:治疗癌症药物的研究

方法:

为此测试进行了队列研究。队列研究是一组具有相似特征的人。在这种情况下,是患者发展成糖尿病。本研究使用了测试用例和控制项。本研究采用条件logistic回归分析。病例对照研究采用条件logistic回归。有一种情况的参与者与没有这种情况的研究参与者进行配对。在这种情况下,参与者都是糖尿病患者,其中一组患有癌症,另一组没有癌症。然而,有第三个对照组来验证药物的影响。由于这是一项队列研究,从1993年开始考虑对患者使用二甲双胍。

结果:

结果表明,没有真正确凿的证据表明,给药已经导致预防或减少了癌症进展的影响。需要更多的参与者来了解这种药物的影响。

结论:

由于已经证明蛋白激酶LKB1可以由二甲双胍药物控制,该药物治疗癌症的潜力已经确定。然而,本研究的结论是,在确定该药物的疗效时,应进行更多的分析和病理生理周期分析。未来的研究将致力于开发这种治疗癌症的药物。

lun wen:治疗癌症药物的研究

Metformin is a drug that is given to the Diabetes type 2 condition. This drug works by targeting the AMP activated protein kinase (AMPK). This makes the muscles use the glucose in the body. Recent research has indicated that AMPK enzyme is used to regulate the protein kinase LKB1. This is a tumor suppressor. Hence, the purpose of this research was to show the use of Metformin for the Diabetes patients in reducing the risk of developing cancer. Using this factor as the background, there was research undertaken to understand the impact of Metformin apart from its use in controlling of the type 2 Diabetes condition.

Participants:

A pilot case controlled study was tested with the database Tayside. The database was titled diabetes clinical information system. A random study was tested on the diabetic patients in the database. All the participants had diabetes 2 condition, some of the people in the study had developed cancer while the others did not have any evidence of cancer.

lun wen:治疗癌症药物的研究

Method:

A cohort study was undertaken for this testing. A cohort study is a group of people with similar characteristics. In this case, it was the patients who had developed Diabetes. There were the test cases and the controls used for this research. Conditional logistic regression was done for this research. Condition logistic regression is used in the case-control study. The participant with one condition is matched with a study participant without the condition. In this case, the participants were all diabetes patients of which one group had cancer and the other group did not have cancer. However, there was the third controlled group to verify the impact of the drug. Since this was a cohort study, the metformin administration of the patients from 1993 was considered.

Result:

The results indicated that there was no real conclusive evidence that the administration of the drug had caused the prevention or reduced the impact of cancer progression. More participants were needed to understand the impact of the drug.

Conclusion:

Since it has been proven that protein kinase LKB1 can be controlled by Metformin drug, the potential of the drug to handle the condition of cancer is established. However, it was concluded in this research that there should be more analysis and pathophysiological cycles analyzed in determining the efficacy of the drug. Future research will be directed towards developing this drug for the treatment of cancer.

论文代写价格:你能逃离网络吗?

论文代写价格:你能逃离网络吗?

网络及其特点

颠覆是当代文化中的一个新词,它与创业和创业联系在一起。它主要是为了扰乱一种正常运作的文化现象,并打破它来吸引消费者对新产品的注意力。这是一种进步,还是仅仅是一种寻求关注的策略?Lepore(2011)谈到了颠覆的危险,以及它是如何建立在不可靠的证据、焦虑和恐慌的综合因素之上的。网络文化自人类诞生以来就一直被人类所吸收,但它并没有出现可追溯的行为,其有效性和必要性从未受到质疑。它被盲目地接受为一种新的文化规范和一种随着时间的推移而成长和繁荣的手段。创新者盲目地倾向于破坏已经运转正常的东西,导致一种恐慌模式,文化的新旧性格特征变得过时,什么都看不出来。事实上,人类一直在适应新的生活方式,从未满足于单一的生活方式。这种颠覆性的态度或文化方面是一种危险的性格特征,它悄无声息地进入我们的生活,抓住了我们每天吹嘘和实践的文化。

Certeau和Rendall(1984)显然在当代文化中提出了生产和消费的要素,在当代文化中,消费者解释产品并消费它,使生产得以生存。这些因素似乎是相辅相成的,而不影响彼此存在的理由。作者强调消费者在消费产品或服务时“使用”它。这就是让人类困惑的地方,他们应该如何处理这些可用的生产单位。消费是一种现象,它已经将文化纳入其中,生产也因此繁荣起来。消费者是沉默的观察者和体验者,当产品被使用时,对他们来说什么都不重要。在日常的生活实践中,隐藏着一系列通过人类自身而起作用的相互关联的活动,而沉默的社会经济秩序支配着社会的日常实践和信仰(Ottwell and Stealey, 2010)。这个社会似乎被这种强加于人的一系列行为所欺骗,这些行为可以使它成为自己的使用和处置手段。要摆脱这种文化因素的干扰实在是太难了,因为它与整个社会的生计息息相关。只有当缺乏正常运转的生活和文化所造成的日益恶化的影响内在化和为人所知时,才能避免这种文化态度。

论文代写价格:你能逃离网络吗?

麦克卢汉(2014)讨论了媒体对人的影响,并要求反思媒体作为人的延伸的问题。他认为,生活在活动中,为体验每一刻而生活,在新时代的文化中迷失了,生活在网上记录生活。科技和社交媒体的这种恶劣影响对社会及其包容基础上的生存都是危险的,因为自恋一旦超越了自身的极限,就没有任何东西可以拯救自己。当自恋抓住了人的理性,甚至不让人内在的灵魂去思考其所有行为的后果时,道德和伦理将作为不朽的名字和实体留在记忆中。当人们观看媒体时,就会产生媒体是否成为人的延伸的问题,这显然引发了关于媒体的真实性及其对人的影响的许多其他问题。这可能与人如何感知外部信息,并将其形成成为自己的一部分的强烈信念有关,因此,人成为媒体的猎物,媒体对他的推理产生了巨大的影响(Elwell, 2010)。人的身份是他向每个人和社会展示的东西,但这种身份是他自己的还是受到媒体的强烈影响?这可能会让人思考人类的推理能力,思考他在追求什么,快乐还是痛苦,以及他与自恋者思维的不断接近。此外,忘记他人,只为自己而活,从而破坏了社会的精神观念及其存在和相关性。媒体在人们的生活中根深蒂固,从人们开始理解媒体的那一天起,它就一直伴随着人们。这令人惊讶地提出了一个问题:人类是有资格拥有自己独特的存在,还是只是媒体想让他思考的一个延伸。在这种情况下,媒体获胜,将一种思想强加于人,人将媒体作为当代文化的一部分,唤醒了对人的个性和身份的破坏,这是人存在的原始状态。当影响局限于自身的地位,不与人的内在信仰体系相融合时,有意地逃离媒体的陷阱是可能的。

论文代写价格:你能逃离网络吗?

The network and its character traits

Disruption is a new buzzword in contemporary culture and is being associated with entrepreneurial and business start-ups. It is primarily meant to disrupt a smooth functioning cultural phenomenon and break it to attract attention of consumers toward a new product. Is this progress or simply a tactic of attention seeking? Lepore (2011) talked about the perils of disruption and how it is founded on the combined elements of shaky evidence, anxiety, and panic. The networked culture in which humankind has been absorbed since its advent is not seeing a retrospective action and its validity and necessity is never been questioned. It is blindly being accepted as a new norm of culture and a means of growing and prospering with time. The innovator is blindly inclined toward disrupting what is already functioning smooth, resulting into a panic mode where the old and new character traits of culture becomes obsolete and nothing is perceptible. In fact, humankind keeps adjusting with the new modes of living and never settle to a single mode of living. This disruptive attitude or aspect of culture is a dangerous character trait that enter our lives without notice and grips the very culture we boast about and practice every day.

Certeau and Rendall (1984) apparently brought forward the elements of production and consumption in contemporary culture in which the consumer interprets the product and consumes it allowing production to survive its life. These elements seem to complement each other without interfering into each other’s reason of existence. The author presses on the subject that the consumer while consuming a product or service ‘makes’ use of it. This is what confuses mankind into what they are supposed to do with these available units of production. Consumption is a phenomenon that has gripped culture into its fold and production thrives on it. The consumer is the silent observer and experiencer to whom nothing matters when the product is used. There is a hidden series of linked activities in the daily practice of life that act itself through humans and the mute socioeconomic order dominates the society’s everyday practice and belief (Ottwell and Stealey, 2010). The society seems to be sold to such imposed series of actions that can bring it to its own means of use and disposal. Escaping this cultural element of disruption is way too difficult, as it is linked with the livelihood of the society as a whole. Escaping this cultural attitude is possible only when the deteriorating impacts of the absence of a smooth functioning life and culture are internalised and known.

论文代写价格:你能逃离网络吗?

McLuhan (2014) discussed the impact of media on man and demanded introspective questions about media being an extension of man. He is of the thinking that living in activity and living for experiencing each moment are lost in the new age culture of living for documenting life online. This dastard impact of technology and social media is dangerous for society and its survival on an inclusive basis, because narcissism when crosses its own limits leaves nothing for its own rescue. Morality and ethics will remain as monumental names and entities in memories when narcissism grips the reasoning of man, not even leaving the very inherent soul of man to think about the consequences of all its acts. When man watches media, the question arises whether the media becomes an extension of man, which apparently raises multiple other questions about the authenticity of the media and its impact on man. This may be associated with how the man perceives external information and forms it into strong beliefs that becomes a part of himself, and thus, man becomes a prey to media and its magnanimous impacts on his reasoning (Elwell, 2010). Man’s identity is what he shows to everyone and society, but is this identity his own or influenced by strong impositions of the media? This may bring one to think about the reasoning abilities of man, about what is he seeking, pleasure or pain, and about his incessant closeness to narcissist thinking. In addition, forgetting about everyone else and living for himself alone, thus destroying the mental notion of society and its existence and relevance. Media is ingrained in man’s life from the day when he starts understanding and it stays with him till the end. This surprisingly raises a question whether man is eligible to his own singular existence or is just an extension of what media wants him to think. Media wins in such cases to impose a thought and man accommodates media as a part of contemporary culture, awakening the destruction of man’s individuality and identity that is primeval to his existence. Escaping the snare of media is possible deliberately when the impact is limited to its own standing and does not mix with the internal belief system of man.

澳洲作业代写:视觉皮层的功能

澳洲作业代写:视觉皮层的功能

其他感觉和运动区域的大小将以线性方式改变。RNA原位杂交用于定量目的(Kok等,2012;梁等,2013)。可以确定的两种可能的结果是原始视觉区域的大小和遗传机制触发的高阶视觉区域之间的线性关系。其次,高阶区域与初级感觉区域成线性关系。

对于第二个问题,HO面积大小将直接或间接受到V1大小的影响。高阶区域与相关的初级感觉区域如初级视觉区域V1呈线性关系(Chou et al ., 2013;Harris和mr sici – flogel, 2013)。其次,以V1大小的双向变化为模型,研究表明,皮层属性等高阶功能的实现不是由于体积的增大,而是由于复杂度的增加。

澳洲作业代写:视觉皮层的功能

在这种情况下,假设有一个基因只在初级视觉皮层表达。在删除后会导致初级视觉皮层V1变小的情况下,可以使用作者假设进行类似的实验。取胚胎发育阶段带有geneX基因的突变小鼠,研究其主要视觉区域,并与正常小鼠进行比较(Harris, and mrsici – flogel, 2013;(Arnal, and Giraud, 2012), geneX的作用将展示遗传机制如何影响V1的生长。其次,对正常水平的geneX小鼠进行研究,然后对剔除geneX的小鼠进行研究。根据作者的论点,即使这种形式的实验表明V1的大小在没有geneX的地方减小,视觉皮层的功能也不会改变。

澳洲作业代写:视觉皮层的功能

Size of other sensory and motor areas will change in a linear way. RNA in-situ hybridization was used for quantification purposes (Kok et al, 2012; Liang et al, 2013). Two likely results that can be identified are that of the linear relationship which is identified between size of primary visual area and higher order visual areas as triggered by genetic mechanisms. And secondly, higher order areas will scale linearly with the primary sensory areas.

For the second question, HO area size would be directly or indirectly influenced by the size of V1. Higher order areas would scale linearly with related primary sensory areas such as primary visual areas V1 (Chou et al, 2013; Harris, and Mrsic-Flogel, 2013). Secondly, with bi-directional changes of V1 size as a model, the study reveals that higher order functions such as cortex properties are not achieved because of increase in size but in complexity.

澳洲作业代写:视觉皮层的功能

Now in this context, assuming that there is geneX which is expressed exclusively in the primary visual cortex. On the condition that if deleted, it could lead to the decrease in size of the primary visual cortex V1, then a similar experiment could be conducted using author hypothesis. Where mutant mice with geneX in embryonic development would be taken and their primary visual area would be studied and compared against that of normal mouse (Harris, and Mrsic-Flogel, 2013; Arnal, and Giraud, 2012), the effect of geneX would show how the genetic mechanism would have an effect on the growth of V1. Secondly, mouse with normal levels of geneX would be studied, and then thirdly, mouse with the geneX removed would be studied. Keeping to the arguments made by the authors, even if this form of an experiment showed that size of V1 decreases where there is not geneX, the functionality of the visual cortex would not change.

assignment 代写:焊接的介绍

assignment 代写:焊接的介绍

2.1。焊接

焊接是两个或两个以上的部件连接在一起,以确保它们完全结合在一起的过程。焊接的目的是确保两种不同或相似的材料连接在一起。这些整体结构的建造通常要经过强度测试和耐久性评估。这些因素对于提高航空航天行业的联合优势非常关键(Li et al., 2008)。传统焊接方法中的问题是LFW等较新的焊接方法产生的原因。焊接通常是通过加热和加压来实现的。焊接形式通常会根据所使用的基材的状态而有所不同。液态焊接又称熔焊和固态焊接,是根据焊接状态特点而产生的焊接形式。

2.2。熔焊

熔焊通常是将基材加热熔化,然后再用于准备连接或任何其他动作。在熔焊过程中,主要的特点之一是没有填充材料。通常会添加填充材料来增加关节的强度或用于其他目的。在熔焊过程中,这种填料是不存在的,焊接操作称为自生焊缝。熔态焊接的几种形式有氧燃料气焊、电弧焊和电阻焊。氧燃料焊接通常是作为切割和分离金属板到零件的单独组合进行的。这里使用的混合物是氧和乙炔,与通常的熔焊状态不同,填充剂可以作为例外(Li et al., 2008)。这里使用的填料通常是用来模拟焊接过程的填料。火焰是由填料产生的,这使得它是一个非常经济和多才多艺的过程使用。它是利用低数量的生产或用于修理作业。另一方面,电弧焊形式的熔焊被认为是一种利用电弧的熔焊。电弧过程增加了焊缝的强度。这是一种良好的联合技术,在汽车机械厂。填充金属在这里再次使用,但只是因为它增加了正在制作的接头的强度。用电极产生电弧,熔化的焊缝就会凝固。电阻焊接不像电弧焊那么常用,它是一种依靠热压技术来实现焊接的焊接方法。这里使用电阻来控制界面上的电流流动,因此这里不需要使用填料(Schubert et al ., 2001)。

assignment 代写:焊接的介绍

2.3。固态焊接

固态焊接不同于熔焊过程,焊接操作是在界面层进行连接或熔合。在这里,两个或两个以上的表面被带入液体或熔融状态,然后关节被创建(Vairis & Frost, 1998)。通常,固态焊接中比较流行的焊接种类是扩散焊,其次是摩擦焊和超声波焊。扩散焊接是在高温高压条件下进行聚结的过程。在扩散焊接的情况下,通常建立在表面的变形是最小的,因此在航空航天应用的背景下,它发现了很多用途(Zink, 2001)。通常不同的材料需要焊接在航空航天工业的情况下,通常是用这种焊接(Abel et al, 2015;Tavares等,2013)。这些都是航空航天工业中使用的传统方法,它们本身存在一些问题和缺陷,这是寻求较新的焊接技术和对其进行分析和评估的原因之一。摩擦焊接属于固态焊接。摩擦焊接是通过表面的摩擦来获得焊接所需的热量的过程。工作部件按常规尺寸组装在一起,通常焊缝的形式是,与熔焊相比,所遇到的缺陷较小(Xin et al ., 2016;布鲁克斯,2015)。超声波焊接也是固态焊接过程的一部分。在超声焊接过程中,零件在压力作用下结合在一起,通过高频振动能实现聚结。焊接通常使用电极或一些超声能量头,这些电极或能量头夹在振荡器下,与焊缝表面平行工作(Sinke, et al ., 2010)。

assignment 代写:焊接的介绍

2.1. Welding

Welding is the process where two or more pieces are joined in order to ensure that they are completely coalesced. The purpose of welding is to ensure that two dissimilar or similar materials are joined. The creation of these monolithic structures is usually tested for strength and assessed for durability as well. These elements are quite critical for increasing join strengths in the case of the aerospace industry (Li et al., 2008). The issues in conventional welding methods are the reasoning behind why newer welding methods such as LFW came into existence. Welding is usually achieved by means of heat and pressure. The forms of welding will usually be different based on the state of base material that is used. Liquid state welding which is called as fusion welding and solid state welding are some of the types based on welding state characteristics.

2.2. Fusion Welding

Fusion welding is where the base material is usually heated to melt before it is used for preparation of joint or any other action. In the case of the fusion welding process, one of the main characteristics is the absence of the filler material. Usually a filler material would be added to increase the strength of the joint or for other purposes. In the case of the fusion welding process such filler is absent and the weld operation is termed as an autogenously weld. Some of the forms of fusion state welding are oxy-fuel gas welding, arc welding and resistance welding. Oxy fuel welding is usually done as a separate mix of cutting and separation of metal plates to parts. Here the mix used is oxygen and acetylene and unlike the usual state of fusion welding a filler can be used as an exception (Li et al., 2008). The filler which is used here is usually one that is seen to imitate the weld process. The flame is produced by the filler and this makes it a very economical and versatile process to use. It is made use of low quantity production or for the use of repair jobs. On the other hand, the fusion welding in the form of arc welding is seen to be one that makes use of the electric arc. The electric arc process adds to the strength of the weld joint. This was a favourable joint technique in auto mechanic works. Filler metal is once again used here but only as it adds to the strength of the joint that is being made. With an electrode of creating an arc, the molten weld will solidify. The Resistance welding is not as commonly used as the arc welding and is one that relies on heat and pressure techniques to achieve the weld. Here an electrical resistance is made use of in order to control current flow at interface and hence it is not required to make use of a filler here (Schubert et al, 2001).

assignment 代写:焊接的介绍

2.3. Solid-state welding

Solid state welding is different from the fusion welding process in that the welding operation will take place as a joining or fusion happening at the interface level. Here two or more surfaces are brought into a liquid or molten state and then the joint is created (Vairis & Frost, 1998). Usually, the welding category that is more popular in the case of solid state welding is the diffusion welding, and secondly friction welding and ultrasonic welding is done. Diffusion welding is a process in which the coalescence is usually achieved at elevated temperature with high pressures. In the case of diffusion welding it is often established that deformation at surface level is minimal and hence in the context of aerospace applications it finds much use (Zink, 2001). Often dissimilar materials that need to be welded in the case of the aerospace industry is usually done with this kind of weld (Abel et al, 2015; Tavares, et al, 2013). These are conventional methods used in the aerospace industry that lend itself some issue and defects, which is one of the reason for the search of newer welding techniques and analysis and assessments of the same. Friction welding comes under solid state welding. Friction welding is the process in which the heat obtained for the welding is usually achieved by means of the rubbing of surfaces. Work parts are held together in a conventional scale and usually the form of weld is such that the defects encountered are seen to be lesser compared to the fusion welds (Xin et al, 2016; Brookes, 2015). The ultrasonic weld is also a part of the solid state weld process. In the ultrasonic weld process, the coalescence is achieved by means of high frequency vibratory energy where parts are held together under pressure. The welding usually occurs with the use of an electrode or some ultrasonic energy tip which is clamped under an oscillator to work in parallel with the weld surface (Sinke, et al, 2010).

ps代写:可变成本法和吸收成本法

ps代写:可变成本法和吸收成本法

在上面的例子中突出的另一个重要方面是,如果公司的销售低于生产,那么在吸收成本的情况下可以实现更高的利润。在生产等于销售的情况下,无论是吸收成本还是可变成本,盈利能力都是相同的。因此,Maria Crane的建议肯定能在财务报表中体现出较高的利润

如果采用吸收成本法,则作为间接费用的一部分发生的成本分为两部分,一部分用于流动资产的开发,即资产负债表上的存货,而另一部分在损益表中作为费用突出显示。这就是在财务报表中应从外部核算间接费用的方法。

另一个突出的方面是内部报告。正如上文所强调的,如果采用吸收成本法,则一旦实现销售,则将成本视为费用,将其视为库存。因此,如果实现低销售,与制造间接费用相关的大部分成本将作为库存消化。因此,虽然盈利能力会提高,但库存会大量积压。换句话说,在吸收成本法下,管理者可以通过建立库存、生产更多的产品来实现不良的激励,因为库存吸收了固定的制造成本,从而导致经营收入的增加。因此,Maria Cane建议采用吸收成本法,这种方法适用于外部报告,也适用于内部报告,这可能不是正确的决定(Watts and Zimmerman, 1986)。

ps代写:可变成本法和吸收成本法

为了克服上述与吸收有关的不足,可以采用数种方法进行内部报告的成本计算。首先,可变成本法也可以与吸收成本法一起使用。这是因为可变成本法产生的营业利润与吸收成本法产生的营业利润相同。因此,比较可变成本法和吸收成本法的营业利润,重点是由于未售出的单位或不需要的库存累积而操纵营业利润。

除上述外,管理当局可采取若干步骤,以减少吸收成本法的不良影响。其中一些如下:

重点做好库存计划,减少管理积压库存的自由。

持有费用的组成部分可以包括在内部会计制度中,这将作为产生过多存货的抑制因素。

这些方面导致基于内部报告的吸收成本法的更好的业绩评价。

ps代写:可变成本法和吸收成本法

Another important aspect which has been highlighted in the above example is that higher profits can be realized in case of absorption costing provided the sales of the company is lower than production. In case the production is equal to sales, the profitability will be same from both absorption and variable costing. Thus, the suggestion by Maria Crane can certainly lead to high profits to be shown in the financial statements

In case of absorption costing the cost incurred as part of overhead is divided in two parts, one of which goes into development of current assets i.e. inventory on the balance sheet, while the other component is highlighted in the income statement as expense. This is the way in which overhead cost should be accounted externally in the financial statements.

Another aspect that has been highlighted is that of internal reporting. As highlighted in the above discussion, in case of absorption costing the cost is considered as expense once sales are realized else, it is considered as inventory. Thus, if low sales is realized, most of the costs related to manufacturing overhead will be absorbed as inventory. As a result of this, although the profitability will increase, there will be huge pile up of inventory. In other words, undesirable incentives can be achieved by the managers under absorption costing with respect to build up of inventory, production of more units as inventory absorbs the fixed manufacturing cost and result in increase of operating income. Therefore, the suggestion of Maria Cane to use absorption costing, which is suitable for external reporting for internal reporting as well may not be correct decision (Watts and Zimmerman, 1986).

ps代写:可变成本法和吸收成本法

To overcome the above deficiency related to absorption, costing for internal reporting several methods may be employed. Firstly, variable costing method may also be used along with the absorption costing method. This is because same amount of operating profit is generated by variable costing as generated by use of absorption costing. Thus, comparison of operating profits from variable costing and absorption costing highlight the manipulation of operating profits as a result of unsold units or undesirable build-up of inventories.

Apart from the above, several steps may be taken by the management to reduce the undesirable effects of absorption costing. Some of these are as follows:

Focus on proper inventory planning in order to reduce the freedom of management to build up excess inventory.

Carrying Charge component may be included in the internal accounting system that will act as disincentive for creating excess inventory.

Such aspects lead to better performance evaluation based on absorption costing for internal reporting.